Animism can be taken to the level of religion, though that's not necessary. Totemism is a form of animism, and many furries follow personal totems.
What happens when such a spirit awakens? What happens when a group of them awaken together?
We've already seen at least two characters like this: a living skyscraper full of cooperating inhabitants, and an intelligent forest with internal life organized to produce thought and action.
The Puzzlebox appears to actively promote the formation and growth of intelligent life. How does this affect these spirits?