Just as technologies of body alteration are common on Puzzlebox, so are methods to redesign mind and thought. The sheer ease of tampering with nature's design has corroded any taboos the locals might have otherwise had about the sanctity of the unaltered mind. (Of course, there are exceptions, like the sober Victorian Retrotech Collective.) Most of the drugs available in the Mess are safe -- and those which are not, are dangerous by design. [ From the web page ]
Drug usage within the culture of The Mess is so profound, common and widespread that it deserves its own discussion. Many, perhaps even most, entities are still partly-to-mostly biological or emulate biological processes to sufficient degree that they can, and do, get intoxicated, stoned, hammered, blotto, entheogenic, or otherwise out of their minds on a regular basis. For those insufficiently meat-like, there are such vast arrays of memetic, informational/viral and 'other' forms of mind-stimulation that the same effects can usually be achieved.
Despite the unimaginably huge variety of drugs available to the denizens, some of the most common ones in play are actually quite ancient and familiar. This may be due to the fondness a great many Mess denizens have for Terran cultural references, biologies and/or neurological formats.
There are several headings to look under for various drugs:
Or, for quick alphabetical reference, the whole shebang: Pharmacopedia
See also: Tasp, Wireheading
OOC: Camilla said she preferred one long page rather than having this broken into subpages. What does everyone else think? - Echo